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Asset / Drug

Pembrolizumab

Drug and asset intelligence for Pembrolizumab with 27 indexed intelligence signals across regulatory, clinical, competitive, and market developments.

Signals
26
Catalysts
1
Stage
Development stage unavailable

Sponsor company

Merck →

Mechanism of action

Monoclonal Antibody

Recent signals(26)

ClinicalJuly 31, 2026

Study of Pembrolizumab Plus MK-1084 in NSCLC with KRAS G12C Mutations

The study aims to evaluate the safety and efficacy of MK-1084 in treating NSCLC patients with KRAS G12C mutations.

CompetitiveJuly 31, 2026

Phase 1/2 Study of Investigational Agents with Pembrolizumab in Advanced Esophageal Cancer

A Phase 1/2 study is underway to evaluate investigational agents with or without pembrolizumab in patients with advanced esophageal squamous cell carcinoma.

Clinical
July 25, 2026

Phase 1 Trial of M3T01 Monotherapy and Combination Therapy in Solid Tumors

A Phase 1 first-in-human trial is underway to evaluate M3T01, a monoclonal antibody targeting FasL, in patients with metastatic or unresectable solid tumors.

ClinicalJuly 24, 2026

Pembrolizumab Trial for Small Cell Carcinoma of Ovary - Hypercalcemic Type

A clinical trial is investigating pembrolizumab as consolidation therapy for SCCOHT.

ClinicalJuly 23, 2026

Pembrolizumab and Lenvatinib Trial for Unresectable Cutaneous Angiosarcoma Initiated

A clinical trial is underway to evaluate the efficacy of pembrolizumab and lenvatinib in patients with unresectable cutaneous angiosarcoma.

ClinicalJuly 22, 2026

Phase I Trial of Pembrolizumab for Neurological Symptoms Post-COVID-19

A Phase I open-label trial is underway to evaluate the safety of pembrolizumab in patients with neurological symptoms following COVID-19.

ClinicalJuly 18, 2026

BRIGHT Trial: Pembrolizumab and Radiation Therapy for Muscle Invasive Bladder Cancer

The BRIGHT trial is a phase II study evaluating pembrolizumab combined with radiation therapy post-chemotherapy to avoid bladder removal in muscle invasive bladder cancer patients.

ClinicalJuly 18, 2026

Merck's Pembrolizumab Study Targets Japanese Pediatric and Adult Cancer Patients

Merck is conducting a study to evaluate the safety and efficacy of pembrolizumab in Japanese pediatric participants with solid tumors and lymphomas, as well as in adults with Merkel cell carcinoma.

ClinicalJuly 11, 2026

Merck's Sacituzumab Tirumotecan in TNBC Shows Potential in Combination with Pembrolizumab

A study is evaluating sacituzumab tirumotecan alone and in combination with pembrolizumab for treating TNBC.

RegulatoryJuly 11, 2026

FDA Approves Pembrolizumab Combinations for Muscle Invasive Bladder Cancer

The FDA has approved pembrolizumab alone or in combination with berahyaluronidase alfa-pmph and enfortumab vedotin-ejfv for muscle invasive bladder cancer.

ClinicalJuly 10, 2026

Pembrolizumab Plus Enzalutamide Trial in mCRPC Shows Promise for Overall Survival

A study is underway to evaluate the efficacy of pembrolizumab combined with enzalutamide in mCRPC patients.

ClinicalJuly 7, 2026

Merck and Daiichi Sankyo Launch ESCC Combination Therapy Study with Pembrolizumab

Merck Sharp & Dohme and Daiichi Sankyo are conducting a study on combination therapies for esophageal squamous cell carcinoma, evaluating pembrolizumab with investigational agents and chemotherapy.

ClinicalJuly 5, 2026

Novel tumor inflammation score predicts outcomes in NSCLC patients treated with pembrolizumab and gemcitabine

A novel tumor inflammation score based on Treg/T cell relationships predicts treatment outcomes better than traditional biomarkers in NSCLC.

ClinicalJuly 5, 2026

Phase 2 Trial of Pembrolizumab for Poor-Prognosis CUP Patients Initiated

A Phase 2 trial has been initiated to evaluate pembrolizumab in treatment-naïve patients with poor-prognosis carcinoma of unknown primary site.

ClinicalJuly 3, 2026

Merck's Sacituzumab Tirumotecan and Pembrolizumab Combo Trial in NSCLC Underway

A clinical trial is comparing sacituzumab tirumotecan combined with pembrolizumab to pembrolizumab alone in NSCLC patients.

ClinicalJune 29, 2026

E-VIRTUE Trial to Evaluate Enfortumab Vedotin with Pembrolizumab in Rare Genitourinary Tumors

The E-VIRTUE trial is investigating the efficacy of enfortumab vedotin with or without pembrolizumab in patients with rare testicular and urinary tract cancers.

CompetitiveJune 28, 2026

Bristol-Myers Squibb Evaluates Pumitamig vs Pembrolizumab in NSCLC Trial

A clinical trial is underway to compare the efficacy of Pumitamig and Pembrolizumab in advanced NSCLC patients with high PD-L1 expression.

RegulatoryJune 25, 2026

FDA approves sacituzumab govitecan-hziy for first-line triple-negative breast cancer

The FDA has approved sacituzumab govitecan-hziy both as a monotherapy and in combination with pembrolizumab for the first-line treatment of triple-negative breast cancer.

ClinicalJune 24, 2026

Merck's Sacituzumab Tirumotecan Trial Targets High-Risk Breast Cancer

Merck is conducting a clinical trial to evaluate sacituzumab tirumotecan in combination with pembrolizumab and chemotherapy for high-risk early-stage breast cancer.

ClinicalJune 24, 2026

Merck's KEYMAKER-U01 Study Explores Pembrolizumab in NSCLC with Chemotherapy

The KEYMAKER-U01 study investigates pembrolizumab alone and in combination with chemotherapy for NSCLC.

ClinicalJune 24, 2026

Phase II Trial of Axelopran with Pembrolizumab in Head and Neck Cancer

A Phase II trial is underway to evaluate axelopran's safety and efficacy with pembrolizumab in R/M HNSCC patients.

RegulatoryJune 22, 2026

FDA approves belzutifan with pembrolizumab for renal cell carcinoma treatment

The FDA has approved belzutifan in combination with pembrolizumab for the adjuvant treatment of renal cell carcinoma.

ClinicalJune 21, 2026

Alnylam's ALN-BCAT Study in Hepatocellular Carcinoma Evaluates Safety and Efficacy

Alnylam Pharmaceuticals is conducting a study to evaluate the safety and antitumor activity of ALN-BCAT, both alone and in combination with pembrolizumab, in patients with hepatocellular carcinoma.

ClinicalJune 18, 2026

Phase III Trial Evaluates Pembrolizumab Timing in NSCLC Treatment

A phase III trial is comparing the efficacy of pembrolizumab alone versus in combination with chemotherapy as first-line treatment for stage IV non-squamous non-small cell lung cancer.

ClinicalJune 18, 2026

Phase III Trial of Pembrolizumab Plus Doxorubicin in Aggressive Sarcomas

A phase III trial is comparing immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) against chemotherapy alone in patients with metastatic or unresectable poorly differentiated sarcomas.

ClinicalJune 17, 2026

Phase III Trial of Pembrolizumab with Chemotherapy in Non-small Cell Lung Cancer

The ALCHEMIST trial is evaluating the efficacy of adding pembrolizumab to standard chemotherapy in resected non-small cell lung cancer.

Upcoming milestones

No catalysts indexed for this entity yet.

Related catalysts(1)

Topline Data

Merck — Pembrolizumab

June 24, 2026 · N/A

Indications

Head and Neck Cancer →
Non-Small Cell Lung Cancer →
NSCLC →

Therapeutic areas

Head and Neck Cancer →
Immunotherapy →
Monoclonal Antibody →
Non-Small Cell Lung Cancer →
NSCLC →
Oncology →
Oncology · Non-small Cell Lung Cancer →
Rare Genitourinary Tumors →
Sarcoma →

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