Clinical
Follow pivotal data releases and trial developments that create new strategic pressure for biotech and pharma operators.
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CLINICAL
A study is investigating the use of banked virus-specific T cells (VSTs) to treat persistent viral infections after allogeneic stem cell transplants.
CLINICAL
Cancer-associated fibroblasts (CAFs) promote the expression of CD39 and CD73 on T cells, leading to increased adenosine synthesis, which may facilitate tumor immune evasion.
CLINICAL
A novel platelet-based delivery system for fluorescein significantly enhances the efficacy of sonodynamic therapy in glioblastoma models.
CLINICAL
A secondary analysis of a randomized controlled trial indicates that mobile app-delivered Acceptance and Commitment Therapy significantly improves PTSD symptoms through mediating components of psychological flexibility.
CLINICAL
DNA polymerase theta (Polθ) is overexpressed in many cancers and is essential for microhomology-mediated end joining, making it a novel therapeutic target.
CLINICAL
A series of phenanthridinone derivatives were synthesized, with compound 3a showing potent TDP1 inhibitory activity and compound 3c demonstrating strong TOP1 inhibition and antitumor efficacy in vivo.
CLINICAL
The PANOVA-3 trial shows that Tumor Treating Fields combined with gemcitabine and nab-paclitaxel improves overall survival and progression-free survival in locally advanced pancreatic cancer patients.
CLINICAL
The study aims to identify markers that predict the risk of sudden cardiac death in patients with moderate left ventricular ejection fraction (LVEF) post-myocardial infarction.
CLINICAL
A recent trial indicates that sodium bicarbonate infusion may improve survival rates in patients with severe metabolic acidosis and acute kidney injury.
CLINICAL
The MyeloMATCH trial is evaluating the efficacy of venetoclax in combination with standard therapies for younger patients with intermediate risk AML.
CLINICAL
The review identifies specific 14-3-3-client modules that contribute to therapy resistance in gastric, colorectal, pancreatic, and hepatobiliary cancers.
CLINICAL
Nanovaccines demonstrated greater efficacy than ampicillin in preventing neonatal listeriosis in a mouse model.
CLINICAL
Compound Kushen Injection (CKI) inhibits glycolysis and immune evasion in HCC cells by reducing O-GlcNAcylation of PD-L1.
CLINICAL
Variants of H. pylori HtrA and CagA influence Wnt/β-catenin signaling, impacting stomach adenocarcinoma progression.
CLINICAL
Astellas Pharma is conducting a double-blind study to evaluate ASP2138 in combination with chemotherapy and pembrolizumab for patients with HER2-negative and CLDN18.2-positive gastric or gastroesophageal junction cancer.
CLINICAL
The National Cancer Institute is testing B7-H3 CAR T cell therapy in patients with refractory small cell lung cancer and extrapulmonary neuroendocrine cancer.
CLINICAL
A study is underway comparing zanubrutinib plus obinutuzumab to lenalidomide plus rituximab in R/R follicular lymphoma and marginal zone lymphoma.
CLINICAL
The CCCG-ALL-2025 trial is designed to enhance event-free survival and overall survival in children with intermediate- and high-risk B-cell ALL.
CLINICAL
Interim PET response of Pola-R-CHP predicts outcomes in untreated CD5-positive DLBCL patients.
CLINICAL
The COPE-A treatment showed significantly greater reductions in PTSD symptom severity compared to supportive counseling at 4 months, with effects maintained at 12 months.
STRATEGY
The VIVACITY-MG3 study highlights significant healthcare resource utilization and economic burden in adults with generalized myasthenia gravis treated with nipocalimab.
CLINICAL
Trichodermin exhibits significant anti-glioblastoma activity by inducing cell cycle arrest and apoptosis, while also enhancing the efficacy of temozolomide.
CLINICAL
A clinical trial is evaluating the efficacy of ketamine in treating Long COVID symptoms, particularly fatigue and cognitive issues.
CLINICAL
Merck is conducting a clinical trial to evaluate the efficacy and safety of MK-2214 in slowing tau protein accumulation in early Alzheimer's disease patients.
CLINICAL
The Opioid Rapid Response System (ORRS) project aims to train citizens in naloxone administration to reduce opioid overdose deaths.
Showing 1–25 of 50 records