Cardiology — Therapeutic Area Intelligence | Humanexa Signals

ClinicalAugust 6, 2026

Trial to Assess Ischemic Preconditioning for AKI Prevention in Juxta-Renal AAA Surgery

A randomized trial is proposed to evaluate local ischemic preconditioning's efficacy in preventing acute kidney injury during open surgery for juxta-renal abdominal aortic aneurysms.

ClinicalAugust 5, 2026

CMR Enhances Surgical Decision-Making in Severe Mitral Regurgitation Patients

Preliminary data indicate that cardiac magnetic resonance (CMR) may improve risk stratification in asymptomatic patients with severe mitral regurgitation (MR).

StrategyAugust 5, 2026

FDA Grants Approval for Dofetilide ANDA212496 by Innogenix Inc.

The FDA has granted approval for the ANDA212496 application for Dofetilide submitted by Innogenix Inc.

RegulatoryAugust 5, 2026

FDA Accepts Supplement for FUROSCIX by SCPHARMACEUTICALS

The FDA has accepted a supplemental application for FUROSCIX, a formulation of furosemide.

ClinicalAugust 4, 2026

MWX205 Study Initiated to Assess Safety and Pharmacokinetics in Dyslipidemia Patients

A clinical trial is underway to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of MWX205 in patients with dyslipidemia.

ClinicalAugust 4, 2026

Trial to Assess Thromboprophylaxis in Postpartum Women at Intermediate Risk for VTE

A randomized controlled trial is being conducted to evaluate the efficacy and safety of LMWH thromboprophylaxis in postpartum women at intermediate risk for VTE.

ClinicalAugust 3, 2026

Study on Livalozet vs High-Intensity Statins in Elderly CAD Patients

A study is evaluating the non-inferiority of Livalozet (Pitavastatin and Ezetimibe) compared to high-intensity statins in elderly patients post-PCI.

RegulatoryAugust 3, 2026

FDA Approves Propranolol Hydrochloride Application ANDA203103

The FDA has approved the ANDA203103 application for Propranolol Hydrochloride submitted by IPCA Labs Ltd.

ClinicalAugust 1, 2026

Study on ST2 Biomarker for Reducing Heart Failure Readmissions

The study evaluates the prognostic value of ST2 in managing heart failure patients to reduce one-month readmissions.

RegulatoryJuly 31, 2026

Aficamten Approved by MHRA and Recommended by NICE for Heart Condition

Aficamten has received approval from the MHRA and a recommendation from NICE for use in patients with a serious heart condition.

RegulatoryJuly 30, 2026

FDA Approves Ticagrelor Application ANDA208539 by Micro Labs

The FDA has approved the original application for Ticagrelor (ANDA208539) submitted by Micro Labs.

ClinicalJuly 30, 2026

Study on TAVI Without Balloon Predilatation Shows Potential for Improved Outcomes

A study is investigating the efficacy of TAVI without balloon predilatation, suggesting potential clinical benefits.

ClinicalJuly 30, 2026

NHLBI Launches MAP-HEART Study to Analyze Heart Failure Phenotypes

The MAP-HEART study aims to collect and analyze biological samples from heart failure patients to identify factors affecting heart function.

RegulatoryJuly 30, 2026

FDA Acceptance of Supplemental NDA for ZIAC by Teva

The FDA has accepted a supplemental NDA for ZIAC, which contains bisoprolol fumarate and hydrochlorothiazide.

ClinicalJuly 30, 2026

Study on Predicting Sudden Cardiac Death Risk in Patients with Moderate LVEF

The study aims to identify markers that predict the risk of sudden cardiac death in patients with moderate left ventricular ejection fraction (LVEF) post-myocardial infarction.

ClinicalJuly 29, 2026

Study on BDNF Levels and Atrial Cardiomyopathy in AF Ablation Patients

A clinical trial is assessing the correlation between circulating BDNF levels and atrial cardiomyopathy in patients undergoing ablation for persistent atrial fibrillation.

RegulatoryJuly 29, 2026

FDA Accepts Supplemental NDA for AVAPRO by Sanofi

The FDA has accepted a supplemental NDA for AVAPRO, indicating ongoing development and potential label expansion.

RegulatoryJuly 29, 2026

FDA Accepts Supplemental NDA for FUROSCIX by SCPHARMACEUTICALS

The FDA has accepted a supplemental NDA for FUROSCIX, a formulation of furosemide.

ClinicalJuly 29, 2026

Study on Myocardial Injury in Rapid Atrial Fibrillation Patients

This observational study aims to assess the relationship between troponin levels, myocardial injury, and coronary artery disease in rapid AF patients.

ClinicalJuly 29, 2026

TVT Registry Launches Mitral Module to Monitor TMVR Outcomes

The TVT Registry has introduced a new module to track outcomes of transcatheter mitral valve repair procedures.

RegulatoryJuly 28, 2026

FDA Grants Approval for Flecainide Acetate by OMSAV Pharma

The FDA has granted approval for Flecainide Acetate under application ANDA218093 submitted by OMSAV Pharma.

ClinicalJuly 28, 2026

Study on IV Iron Therapy for HFpEF Patients with Iron Deficiency Initiated

A new trial is investigating the efficacy of intravenous iron therapy in improving symptoms and quality of life in patients with heart failure with preserved ejection fraction (HFpEF) and iron deficiency.

ClinicalJuly 28, 2026

Study on VTE Prevention in Hip and Knee Arthroplasty Comparing Aspirin and Rivaroxaban

A clinical trial is comparing the efficacy of aspirin alone versus aspirin combined with rivaroxaban for VTE prevention in patients undergoing total hip and knee arthroplasty.

RegulatoryJuly 28, 2026

FDA Submission Overview for Vericiguat by Torrent Pharmaceuticals

Torrent Pharmaceuticals has submitted an original application for Vericiguat (ANDA220221) to the FDA, currently under standard review.

ClinicalJuly 28, 2026

CCTA May Enhance Risk Stratification for Atrial Fibrillation Ablation Outcomes

A study is evaluating the predictive value of CCTA parameters for post-ablation outcomes in atrial fibrillation patients.

ClinicalJuly 28, 2026

Gaia AG trials digital health app Liebria for primary hypertension

A clinical trial is underway to evaluate the effectiveness of the Liebria digital health application in managing primary hypertension.

RegulatoryJuly 27, 2026

Ziresovir TQT Study Initiated by Shanghai Ark Biopharma

A TQT clinical study evaluating ziresovir's effects on cardiac repolarization has been initiated.

ClinicalJuly 27, 2026

Novartis initiates study on DII235 for elevated lipoprotein(a)

Novartis is conducting a clinical trial to evaluate the safety and efficacy of DII235 in adults with elevated lipoprotein(a).

RegulatoryJuly 26, 2026

FDA Submission Update for Bosentan by Zydus Pharms

Zydus Pharms has submitted a supplemental application for Bosentan under ANDA207760, currently under standard review.

RegulatoryJuly 26, 2026

FDA Grants AP Status for Bosentan ANDA207110 by Watson Labs

The FDA has granted approval status (AP) for Watson Labs' ANDA207110 for Bosentan.

ClinicalJuly 26, 2026

Registry Launched to Evaluate Farapulse PFA Technology for Atrial Fibrillation

The DISRUPT-AF Registry aims to gather real-world clinical data on the Farapulse Pulsed Field Ablation System for AF treatment.

ClinicalJuly 26, 2026

Johnson & Johnson's Varipulse Catheter Study Targets Paroxysmal Atrial Fibrillation

A clinical trial is underway to evaluate the long-term effectiveness of the Varipulse Catheter in patients with paroxysmal atrial fibrillation under optimized sedation.

RegulatoryJuly 25, 2026

FDA Approves Cangrelor for Market Release

The FDA has granted approval for Cangrelor under application ANDA213703, submitted by MSN.

ClinicalJuly 25, 2026

Study on Improving Hypertension Medication Adherence in HIV Patients

A study aims to address barriers to antihypertensive medication adherence among persons living with HIV who have achieved viral suppression.

ClinicalJuly 23, 2026

Study on Smartphone-Based Heart Sound Analysis Using AI

The University of Hong Kong is conducting an observational study to evaluate the ausculto™ software for analyzing heart sounds via smartphones.

ClinicalJuly 22, 2026

Study Compares PCI vs CABG in Diabetic Patients with Three-Vessel CAD

A randomized study is underway to compare imaging-and physiology-guided PCI with CABG in diabetic patients with three-vessel CAD.

ClinicalJuly 22, 2026

Metformin Trial Post-LVAD Implantation to Assess Cardiac Function Improvement

A multicenter trial will evaluate the efficacy of metformin in improving cardiac function in LVAD patients over 12 months.

ClinicalJuly 21, 2026

Endotronix Initiates PROACTIVE-HF-2 Trial for Cordella System in Heart Failure Patients

The PROACTIVE-HF-2 trial is evaluating the safety and efficacy of the Cordella Pulmonary Artery Sensor System in patients with NYHA Class II and III heart failure.

ClinicalJuly 21, 2026

Merck's Sotatercept Study for Pulmonary Arterial Hypertension Launches in India

Merck Sharp & Dohme is conducting a study to evaluate the safety and tolerability of sotatercept in combination with standard treatments for PAH in India.

ClinicalJuly 20, 2026

Pilot Study on HEMO-INTEGRA for Intraoperative Hemodynamic Monitoring in Cardiac Surgery

The HEMO-INTEGRA system integrates multiple hemodynamic monitoring domains into a single dashboard during cardiac surgery.

ClinicalJuly 20, 2026

Tasly Pharma Trials Qishen Yiqi Pills for Chronic Heart Failure

Tasly Pharmaceutical is conducting a trial to assess the efficacy and safety of Qishen Yiqi Dripping Pills for chronic heart failure with reduced ejection fraction.

RegulatoryJuly 19, 2026

FDA Grants AP Status for Verapamil Hydrochloride ANDA211015

The FDA has granted approval status (AP) for the ANDA211015 application for Verapamil Hydrochloride submitted by Somerset Therap LLC.

RegulatoryJuly 19, 2026

FDA Accepts Supplemental Application for Macitentan by Seasons Biotech

The FDA has accepted a supplemental application for Macitentan submitted by Seasons Biotech.

StrategyJuly 19, 2026

FDA Grants Approval for Isoproterenol Hydrochloride ANDA220299

The FDA has granted approval for ANDA220299, a generic formulation of Isoproterenol Hydrochloride, submitted by ASPIRO.

CompetitiveJuly 18, 2026

FDA Approves First Oral PCSK9 Inhibitor Lipfendra for High Cholesterol

The FDA has approved Lipfendra (enlicitide), the first oral PCSK9 inhibitor for lowering LDL cholesterol in adults.

StrategyJuly 18, 2026

Merck's LIPFENDRA Approved as First Oral PCSK9 Inhibitor for Hypercholesterolemia

LIPFENDRA (enlicitide) is the first FDA-approved oral PCSK9 inhibitor, significantly reducing LDL-C by up to 59%.

ClinicalJuly 17, 2026

Medtronic's Study on Left Bundle Branch Optimized CRT for Heart Failure Outcomes

Medtronic is conducting a feasibility study to evaluate the efficacy of Left Bundle Branch Optimized Cardiac Resynchronization Therapy (LOT-CRT) compared to standard LBBAP in heart failure patients.

ClinicalJuly 17, 2026

Study on Integrated Care for Atrial Fibrillation and Heart Failure in Rural China

A cluster randomization study is comparing integrated care led by village doctors to usual care for older patients.

RegulatoryJuly 16, 2026

FDA Submission for Finerenone by Macleods Pharmaceuticals

Macleods Pharmaceuticals has submitted an ANDA for Finerenone, currently under review.

ClinicalJuly 16, 2026

DAPT Duration Post-PCI: No Cardiovascular Benefit, Increased Bleeding in CKD Patients

No significant differences in cardiovascular events were found across DAPT duration groups in ACS patients, but prolonged DAPT (≥7 months) increased major bleeding risk in CKD patients.

RegulatoryJuly 16, 2026

FDA Accepts Supplement for CARDIOGEN-82 by BRACCO

The FDA has accepted a supplemental application for CARDIOGEN-82, a radiopharmaceutical used in cardiac imaging.

StrategyJuly 15, 2026

FDA Grants AP Status for Spironolactone ANDA219494 by Graviti Pharms

The FDA has granted an Abbreviated New Drug Application (ANDA) approval status for Spironolactone submitted by Graviti Pharms.

CompetitiveJuly 15, 2026

AI-Based Echocardiography Trial for Aortic Stenosis Launched by Caption Health

Caption Health is conducting a clinical trial to validate an AI-based algorithm for assessing aortic stenosis using point-of-care echocardiography.

StrategyJuly 15, 2026

FDA Grants AP Status for Spironolactone ANDA203512 by Accord Healthcare

The FDA has granted an Abbreviated New Drug Application (ANDA) approval status for Spironolactone submitted by Accord Healthcare.

StrategyJuly 15, 2026

FDA Grants AP Status for Spironolactone ANDA217761 by Annora Pharma

The FDA has granted Abbreviated Approval (AP) status for Annora Pharma's ANDA217761 for spironolactone.

RegulatoryJuly 14, 2026

FDA Accepts Supplement Application for RIOCIGUAT by MSN

The FDA has accepted a supplemental application for RIOCIGUAT submitted by MSN.

CompetitiveJuly 14, 2026

Medtronic Recalls Harmony Delivery Catheter Due to Detachment Risk

Medtronic has recalled certain lots of the Harmony Delivery Catheter System due to a risk of the distal tip detaching.

ClinicalJuly 14, 2026

Anthos and Novartis initiate LILAC-TIMI 76 trial for abelacimab in high-risk AF patients

The LILAC-TIMI 76 study is evaluating abelacimab's efficacy and safety in high-risk atrial fibrillation patients unsuitable for oral anticoagulation.

ClinicalJuly 14, 2026

AstraZeneca's Dapagliflozin Approved for Heart Failure; Real-World Study Launched in Germany

Dapagliflozin has been approved by the European Commission for heart failure treatment, applicable to all patients regardless of ejection fraction or diabetes status.

RegulatoryJuly 14, 2026

FDA Accepts Supplement for ADEMPAS (Riociguat) by Bayer Healthcare

The FDA has accepted a supplemental application for ADEMPAS (Riociguat) from Bayer Healthcare.

RegulatoryJuly 13, 2026

FDA Approves Supplemental Application for BRILINTA (Ticagrelor)

The FDA has approved a supplemental application for BRILINTA, a medication containing ticagrelor, submitted by AstraZeneca.

ClinicalJuly 12, 2026

Study on Ventilation During CPB in Cardiac Surgery to Assess Lung Outcomes

This study investigates the impact of lung ventilation during cardiopulmonary bypass on lung collapse and postoperative outcomes.

RegulatoryJuly 12, 2026

GSK's Bepirovirsen Study Evaluates Cardiac Conduction Impact in Healthy Volunteers

A study is underway to assess the impact of bepirovirsen on cardiac conduction, specifically the QT interval.

ClinicalJuly 12, 2026

CAPTURE AMI Trial Evaluates Mechanical Thrombectomy in STEMI Patients

The CAPTURE AMI trial is assessing the efficacy of sustained mechanical thrombectomy versus standalone PCI in STEMI patients with high thrombus burden.

ClinicalJuly 10, 2026

Study on Phoenixin-14 Levels in Infants of Diabetic Mothers

The study investigates the correlation between echocardiographic pathologies and serum phoenixin-14 levels in infants of diabetic mothers.

RegulatoryJuly 9, 2026

FDA Grants AP Status for Sotalol Hydrochloride ANDA207428

The FDA has granted an Abbreviated New Drug Application (ANDA) approval status for Sotalol Hydrochloride submitted by Regcon Holdings.

RegulatoryJuly 9, 2026

FDA Approval Letter for Verapamil Hydrochloride ANDA078306

The FDA has issued an approval letter for the ANDA078306 application for Verapamil Hydrochloride.

CompetitiveJuly 9, 2026

SELECT TAVR Trial to Compare Myval and Evolut Valves in Borderline Annuli Patients

The SELECT TAVR trial will assess the noninferiority of Myval transcatheter heart valves compared to Evolut valves in patients with borderline annular dimensions.

ClinicalJuly 9, 2026

AstraZeneca's Wainua fails primary endpoint in ATTR-CM Phase III trial

The CARDIO-TTRansform Phase III trial for Wainua (eplontersen) did not meet its primary efficacy endpoint.

ClinicalJuly 9, 2026

SINGLE-AF Trial Evaluates DOACs in Intermediate Stroke Risk Atrial Fibrillation Patients

The SINGLE-AF trial is assessing the efficacy of direct oral anticoagulants in patients with atrial fibrillation at intermediate stroke risk.

ClinicalJuly 8, 2026

Innovative MRI Methods for Characterizing Heart Failure With Preserved Ejection Fraction

A study is underway to develop advanced MRI techniques for assessing microvascular remodeling in HFpEF.

ClinicalJuly 7, 2026

Study on Non-Invasive Median Nerve Stimulation for Atrial Fibrillation Post-Ablation

A clinical trial is assessing the efficacy of the CardiaCare RR2 wearable device for reducing atrial arrhythmias after AF ablation.

ClinicalJuly 6, 2026

Boston Medical Center Study on Ultrasound for Heart Failure Management

A study is underway to evaluate the effectiveness of a novel ultrasound technique in predicting volume overload in heart failure patients.

RegulatoryJuly 5, 2026

FDA Grants Approval for Flecainide Acetate ANDA218093 by OMSAV PHARMA

The FDA has granted approval for the ANDA218093 application for Flecainide Acetate submitted by OMSAV PHARMA.

StrategyJuly 5, 2026

Torrent Pharmaceuticals submits ANDA for Vericiguat

Torrent Pharmaceuticals has submitted an Abbreviated New Drug Application (ANDA) for Vericiguat.

ClinicalJuly 4, 2026

Pilot Trial on Palliative Care for Advanced Heart Failure Shows Innovative Methodology

A pilot trial is assessing the feasibility and efficacy of a palliative care intervention for older adults with advanced heart failure.

ClinicalJuly 4, 2026

NHLBI Study on Dyslipidemias Evaluates Lipid Disorders and Their Impact

The NHLBI is conducting a study to evaluate individuals with dyslipidemias, focusing on lipid levels and related health risks.

RegulatoryJuly 3, 2026

FDA Approval Status Update for Bosentan ANDA207760 by Zydus Pharmaceuticals

The FDA has granted an Abbreviated New Drug Application (ANDA) approval status of 'AP' for Bosentan submitted by Zydus Pharmaceuticals.

ClinicalJuly 3, 2026

Cook Research initiates RCT for Evero DCB in PAD treatment

The Evero drug-coated balloon is being evaluated for long-term safety and effectiveness against paclitaxel DCBs in PAD.

RegulatoryJuly 3, 2026

Abiomed Recalls Impella CP Sets Due to Low Purge Pressure Risk

Abiomed has recalled specific Impella CP Sets due to out-of-specification conditions that may lead to low purge pressure events.

ClinicalJuly 3, 2026

Dapagliflozin Trial for Renal Protection in Heart Transplant Recipients Initiated

The DAPARHT trial is evaluating dapagliflozin's efficacy in preventing renal function deterioration in heart transplant recipients.

ClinicalJuly 2, 2026

Trial on Moxifloxacin's Impact on QTc Interval in T2DM Patients Initiated

A clinical trial is investigating the effects of moxifloxacin on QTc interval in patients with Type 2 diabetes, focusing on the interaction with hyperglycaemia.

ClinicalJuly 2, 2026

Study Evaluates Safety of Cardiac MRI in High-Risk Patients with Implanted Leads

A prospective cohort study is underway to assess the safety of cardiac MRI in patients with abandoned or fractured endocardial leads.

ClinicalJuly 1, 2026

Mobile Technology May Enhance Cardiac Rehabilitation Participation Post-Acute Coronary Syndrome

A study is exploring the use of mobile technology to improve participation in cardiac rehabilitation after acute coronary syndrome, where current utilization is below 30%.

ClinicalJuly 1, 2026

Novo Nordisk's NNC0487-0111 Trial Targets Heart Failure with Obesity

Novo Nordisk is conducting a trial to evaluate the safety and efficacy of NNC0487-0111 in patients with HFpEF or HFmrEF and obesity compared to placebo.

CompetitiveJuly 1, 2026

Phase 1/2 Trial of AFTX-201 in BAG3-Associated Dilated Cardiomyopathy Initiated

Affinia Therapeutics has launched Phase 1/2 trial for AFTX-201 targeting BAG3-associated dilated cardiomyopathy.

ClinicalJuly 1, 2026

New Prospective Cohort Study on Acute Cardiovascular Referrals Launched

A prospective cohort study has been initiated to assess the diagnostic yield of acute cardiovascular referrals in an ambulatory setting.

CompetitiveJuly 1, 2026

First-in-Human Study of MOTHER-DAUGHTER DES System for PCI Bifurcation Lesions

The study evaluates the feasibility of the MOTHER-DAUGHTER side-branch access drug-eluting stent system in patients undergoing PCI.

RegulatoryJune 30, 2026

FDA Grants AP Status for Sotalol Hydrochloride ANDA207429

The FDA has granted approval status (AP) for the ANDA207429 application for Sotalol Hydrochloride submitted by Regcon Holdings.

StrategyJune 30, 2026

FDA Grants Approval for Propranolol Hydrochloride ANDA217238

The FDA has granted approval for the ANDA217238 application for Propranolol Hydrochloride submitted by Micro Labs.

ClinicalJune 29, 2026

NHLBI Launches Study on 18F-FAPI-74 PET/CT Imaging for Early Detection of Fibrosis

The NHLBI is conducting a trial to evaluate the efficacy of 18F-FAPI-74 PET/CT imaging in detecting early-stage fibrosis in heart and lung diseases.

RegulatoryJune 29, 2026

Abiomed Issues Update on Automated Impella Controllers Due to Software Error

A software error may cause the Automated Impella Controller to restart when used with left ventricular Impella devices.

ClinicalJune 29, 2026

Trial on Vasopressor Agents for Pulmonary Hypertension Crisis Initiated

A prospective, randomized controlled trial is underway to compare the efficacy and safety of dopamine, norepinephrine, and epinephrine in treating pulmonary hypertension crisis.

ClinicalJune 28, 2026

Study Compares P-CAB vs. GI Protection in AMI Patients Undergoing PCI

The study will evaluate the effectiveness of potassium competitive acid blockers compared to standard GI protection in AMI patients receiving DAPT.

ClinicalJune 28, 2026

Trial Evaluates Dual vs Triple Lipid-Lowering Therapy in Type 2 Diabetes Patients

A clinical trial is underway to compare the efficacy and safety of dual versus triple lipid-lowering therapy in patients with type 2 diabetes and elevated LDL cholesterol.

ClinicalJune 28, 2026

Study Compares Focal Cryoablation to RF Ablation for Bradyarrhythmias

A study is underway to compare the safety and efficacy of focal cryoablation versus radiofrequency ablation in treating bradyarrhythmias.

ClinicalJune 28, 2026

Study on Inspiratory Muscle Strength Training for Obesity-Related Hypertension

A clinical trial is investigating the impact of inspiratory muscle strength training on blood pressure in obese adults.

ClinicalJune 28, 2026

Zoll Medical's HFMS Device Trial Aims to Enhance Heart Failure Management Post-Hospitalization

A clinical trial is evaluating the effectiveness of the Heart Failure Management System (HFMS) device in improving patient outcomes after hospitalization for heart failure.

ClinicalJune 27, 2026

Study on Ultimaster Stents Evaluates Real-World Effectiveness and Safety

A clinical trial is underway to assess the effectiveness and safety of Ultimaster Tansei and Nagomi stents in routine clinical practice.

ClinicalJune 27, 2026

Swedish Study on Infective Endocarditis Aims to Improve Treatment Outcomes

An observational study in Sweden aims to enhance understanding of infective endocarditis by analyzing clinical characteristics and treatment outcomes.

RegulatoryJune 27, 2026

FDA Accepts Supplement Application for Bosentan by Natco Pharma

The FDA has accepted a supplemental application for Bosentan submitted by Natco Pharma.

ClinicalJune 26, 2026

Bayer's Study on Nitroglycerin and Nurandociguat Safety in CAD Patients

A clinical trial is underway to assess the safety and interaction of nitroglycerin and nurandociguat in patients with coronary artery disease.

ClinicalJune 26, 2026

Trial to Compare Bleeding Risk of Rivaroxaban vs Apixaban in Acute VTE Treatment

A new trial is underway to compare the bleeding risk of rivaroxaban and apixaban in treating acute venous thromboembolism.

ClinicalJune 25, 2026

Study on Mannitol for Delirium Prevention in Myocardial Infarction Patients

A clinical trial is evaluating the efficacy of mannitol as an adjuvant treatment to prevent delirium in myocardial infarction patients.

ClinicalJune 25, 2026

Isometric Resistance Exercise May Improve BP Control in Hypertension Patients

A randomized controlled trial is evaluating the effects of isometric resistance exercise on blood pressure and atherosclerosis in hypertensive patients.

ClinicalJune 25, 2026

Study on Surgical Treatment Efficacy for Ascending Aortic Aneurysm

The study aims to evaluate the efficacy of surgical treatment for ascending aortic aneurysm and assess negative clinical outcomes in non-operated patients.

ClinicalJune 25, 2026

Sanofi's Venglustat Phase 3 Trial Targets Left Ventricular Mass in Fabry Disease

Sanofi is conducting Phase 3 trial to assess the efficacy of venglustat on left ventricular mass index in Fabry disease patients.

ClinicalJune 24, 2026

Novartis initiates trial for inclisiran in acute coronary syndromes

Novartis is evaluating inclisiran's efficacy and safety in patients with acute coronary syndromes, initiated early in the hospital.

ClinicalJune 24, 2026

Merck's Enlicitide Study Aims to Enhance LDL-C Reduction with Rosuvastatin

Merck is conducting a clinical trial to evaluate the efficacy of enlicitide in combination with rosuvastatin for lowering LDL-C levels.

ClinicalJune 23, 2026

Study on Predictors of Functional Capacity Improvement Post-TAVI

A study is underway to identify clinical and cardiopulmonary exercise testing parameters that predict improvement in functional capacity after TAVI.

RegulatoryJune 23, 2026

FDA Accepts Supplement for POKONZA by Genus Lifesciences

The FDA has accepted a supplemental application for POKONZA, an electrolyte replacement therapy containing potassium chloride.

StrategyJune 23, 2026

FDA Grants Approval for Macitentan ANDA211187 by Teva Pharmaceuticals

Teva Pharmaceuticals has received approval for its Abbreviated New Drug Application (ANDA211187) for Macitentan.

ClinicalJune 23, 2026

Study on Unipolar Voltage Mapping for Personalized Atrial Fibrillation Ablation Initiated

A clinical trial is underway to evaluate unipolar voltage mapping for personalized catheter ablation in atrial fibrillation patients.

RegulatoryJune 22, 2026

FDA Accepts Application for Macitentan by Amneal

The FDA has accepted the application for Macitentan under ANDA211000 submitted by Amneal.

ClinicalJune 22, 2026

New Strategy for Identifying Unstable Coronary Plaque in Emergency Chest Pain Patients

A study is underway to implement a primary prevention strategy using calcium scoring and 18F-Na PET scans to identify unstable coronary plaques in emergency department patients.

RegulatoryJune 22, 2026

Abiomed Issues Correction for Automated Impella Controllers Due to Safety Concerns

Abiomed has announced that certain Automated Impella Controllers require hardware updates to mitigate potential safety risks.

ClinicalJune 22, 2026

Study on Obesity and Heart Disease Risk Factors in African Americans Launched

A new study aims to explore the relationship between obesity and heart disease risk factors in African American men and women, focusing on body size and sex differences.

ClinicalJune 22, 2026

Weight loss reduces antihypertensive treatment in type 2 diabetes patients

Weight loss in type 2 diabetes patients may lead to a reduction in the need for antihypertensive medications.

ClinicalJune 22, 2026

Clinical Trial on Video Monitoring for Heart Failure Patients Launched

A randomized clinical trial is assessing the effectiveness of video monitoring versus audio calls for heart failure patients.

CompetitiveJune 22, 2026

Eko Devices Initiates Study on Detecting Pulmonary Hypertension with Electronic Stethoscope

Eko Devices is conducting a study to evaluate the effectiveness of its DUO stethoscope in detecting pulmonary hypertension (PH) through phonocardiography.

RegulatoryJune 21, 2026

Study on Chronic E-Cigarette Usage and Microvascular Health Initiated

A study led by Virginia Commonwealth University is examining the effects of chronic e-cigarette use on microvascular health.

ClinicalJune 21, 2026

Dapagliflozin Evaluated for Right Ventricular-Pulmonary Artery Coupling Post-OPCAB

A study is underway to assess the impact of dapagliflozin on right ventricular-pulmonary artery coupling in heart failure patients post-surgery.

StrategyJune 20, 2026

Cost-effectiveness of Mavacamten in Obstructive Hypertrophic Cardiomyopathy Assessed

The study evaluates the cost-effectiveness of mavacamten combined with standard therapies for symptomatic obstructive HCM.

ClinicalJune 20, 2026

Limited FDA-approved Antihypertensive Therapies for Pediatric Patients Highlighted

There is a significant unmet medical need for antihypertensive therapies in pediatric patients, especially those under six years old.

ClinicalJune 20, 2026

HEARTFELT Study Evaluates Remote Monitoring Device for Heart Failure Management

The HEARTFELT study is assessing the safety and effectiveness of a remote patient monitoring device for heart failure patients.

ClinicalJune 20, 2026

Yale University Launches Digital Health Initiative for Heart Failure in Uganda

Yale University is implementing a digital-first care model for heart failure in Uganda, evaluating its effectiveness through a cluster-randomized trial.

ClinicalJune 19, 2026

Guidance on Distinction Between Angioedema Types for ACE-Inhibitor Users

Healthcare professionals are advised about the delayed onset of angioedema and the differing treatment strategies for bradykinin- versus histamine-mediated cases.

RegulatoryJune 19, 2026

Medline Industries Expands Catheter Recall Due to Infection Risk

Medline Industries has expanded a recall of reprocessed electrophysiology and ultrasound catheters due to potential contamination risks.

ClinicalJune 18, 2026

Study on Riociguat's Impact on Right Heart Function in PAH and CTEPH

A clinical study is underway to assess the effects of riociguat on right ventricular size and function in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH).

ClinicalJune 18, 2026

Digital Management Improves Outcomes in Early Cardiogenic Shock Patients

A clinical trial involving 472 patients with early-stage cardiogenic shock evaluated the HeartMed-HF digital management system, showing potential benefits over standard discharge guidance.

ClinicalJune 18, 2026

Study on Optimizing CRT Lead Placement for Non-LBBB Patients Using Advanced Imaging Techniques

The RESYNC-PETCT study aims to improve CRT response in heart failure patients with non-LBBB or narrow LBBB patterns through advanced imaging guidance.

ClinicalJune 17, 2026

NORM-HF Study to Evaluate FIRE1 NORM™ System in Heart Failure Management

The NORM-HF study aims to show that the FIRE1 NORM™ System is superior to standard care in managing heart failure.

ClinicalJune 17, 2026

Trial on S-ICD Implantation Without Defibrillation Testing Shows Non-Inferiority

A randomized trial is assessing whether S-ICD implantation without defibrillation testing is non-inferior to the standard method.

ClinicalJune 17, 2026

Study on PSB Pacing to Prevent Atrial Fibrillation in Sinus Node Dysfunction Patients

A clinical trial is evaluating the effectiveness of posterosuperior bundle pacing in reducing atrial fibrillation incidence in patients with sinus node dysfunction.

ClinicalJune 14, 2026

Rivaroxaban Trial for Antithrombotic Prevention in Hypertrophic Cardiomyopathy Patients

A clinical trial is proposed to evaluate the use of rivaroxaban for stroke prevention in hypertrophic cardiomyopathy patients with abnormal left atrial strain.

ClinicalJune 2, 2026

Trial on Pulmonary Artery Catheters in Cardiac Surgery Aims to Compare Recovery Outcomes

This clinical trial will evaluate the impact of avoiding pulmonary artery catheters on recovery outcomes in cardiac surgery patients.

RegulatoryJune 1, 2026

AstraZeneca's Baxfendy Receives US Approval for Hypertension as First-in-Class Treatment

Baxfendy has been approved in the US as the first and only aldosterone synthase inhibitor for adults with hypertension, showing a significant reduction in systolic blood pressure.

Companies

Assets

Recent signals(137)

Trial to Assess Ischemic Preconditioning for AKI Prevention in Juxta-Renal AAA Surgery

CMR Enhances Surgical Decision-Making in Severe Mitral Regurgitation Patients

FDA Grants Approval for Dofetilide ANDA212496 by Innogenix Inc.

FDA Accepts Supplement for FUROSCIX by SCPHARMACEUTICALS

MWX205 Study Initiated to Assess Safety and Pharmacokinetics in Dyslipidemia Patients

Trial to Assess Thromboprophylaxis in Postpartum Women at Intermediate Risk for VTE

Study on Livalozet vs High-Intensity Statins in Elderly CAD Patients

FDA Approves Propranolol Hydrochloride Application ANDA203103

Study on ST2 Biomarker for Reducing Heart Failure Readmissions

Aficamten Approved by MHRA and Recommended by NICE for Heart Condition

FDA Approves Ticagrelor Application ANDA208539 by Micro Labs

Study on TAVI Without Balloon Predilatation Shows Potential for Improved Outcomes

NHLBI Launches MAP-HEART Study to Analyze Heart Failure Phenotypes

FDA Acceptance of Supplemental NDA for ZIAC by Teva

Study on Predicting Sudden Cardiac Death Risk in Patients with Moderate LVEF

Study on BDNF Levels and Atrial Cardiomyopathy in AF Ablation Patients

FDA Accepts Supplemental NDA for AVAPRO by Sanofi

FDA Accepts Supplemental NDA for FUROSCIX by SCPHARMACEUTICALS

Study on Myocardial Injury in Rapid Atrial Fibrillation Patients

TVT Registry Launches Mitral Module to Monitor TMVR Outcomes

FDA Grants Approval for Flecainide Acetate by OMSAV Pharma

Study on IV Iron Therapy for HFpEF Patients with Iron Deficiency Initiated

Study on VTE Prevention in Hip and Knee Arthroplasty Comparing Aspirin and Rivaroxaban

FDA Submission Overview for Vericiguat by Torrent Pharmaceuticals

CCTA May Enhance Risk Stratification for Atrial Fibrillation Ablation Outcomes

Gaia AG trials digital health app Liebria for primary hypertension

Ziresovir TQT Study Initiated by Shanghai Ark Biopharma

Novartis initiates study on DII235 for elevated lipoprotein(a)

FDA Submission Update for Bosentan by Zydus Pharms

FDA Grants AP Status for Bosentan ANDA207110 by Watson Labs

Registry Launched to Evaluate Farapulse PFA Technology for Atrial Fibrillation

Johnson & Johnson's Varipulse Catheter Study Targets Paroxysmal Atrial Fibrillation

FDA Approves Cangrelor for Market Release

Study on Improving Hypertension Medication Adherence in HIV Patients

Study on Smartphone-Based Heart Sound Analysis Using AI

Study Compares PCI vs CABG in Diabetic Patients with Three-Vessel CAD

Metformin Trial Post-LVAD Implantation to Assess Cardiac Function Improvement

Endotronix Initiates PROACTIVE-HF-2 Trial for Cordella System in Heart Failure Patients

Merck's Sotatercept Study for Pulmonary Arterial Hypertension Launches in India

Pilot Study on HEMO-INTEGRA for Intraoperative Hemodynamic Monitoring in Cardiac Surgery

Tasly Pharma Trials Qishen Yiqi Pills for Chronic Heart Failure

FDA Grants AP Status for Verapamil Hydrochloride ANDA211015

FDA Accepts Supplemental Application for Macitentan by Seasons Biotech

FDA Grants Approval for Isoproterenol Hydrochloride ANDA220299

FDA Approves First Oral PCSK9 Inhibitor Lipfendra for High Cholesterol

Merck's LIPFENDRA Approved as First Oral PCSK9 Inhibitor for Hypercholesterolemia

Medtronic's Study on Left Bundle Branch Optimized CRT for Heart Failure Outcomes

Study on Integrated Care for Atrial Fibrillation and Heart Failure in Rural China

FDA Submission for Finerenone by Macleods Pharmaceuticals

DAPT Duration Post-PCI: No Cardiovascular Benefit, Increased Bleeding in CKD Patients

FDA Accepts Supplement for CARDIOGEN-82 by BRACCO

FDA Grants AP Status for Spironolactone ANDA219494 by Graviti Pharms

AI-Based Echocardiography Trial for Aortic Stenosis Launched by Caption Health

FDA Grants AP Status for Spironolactone ANDA203512 by Accord Healthcare

FDA Grants AP Status for Spironolactone ANDA217761 by Annora Pharma

FDA Accepts Supplement Application for RIOCIGUAT by MSN

Medtronic Recalls Harmony Delivery Catheter Due to Detachment Risk

Anthos and Novartis initiate LILAC-TIMI 76 trial for abelacimab in high-risk AF patients

AstraZeneca's Dapagliflozin Approved for Heart Failure; Real-World Study Launched in Germany

FDA Accepts Supplement for ADEMPAS (Riociguat) by Bayer Healthcare

FDA Approves Supplemental Application for BRILINTA (Ticagrelor)

Study on Ventilation During CPB in Cardiac Surgery to Assess Lung Outcomes

GSK's Bepirovirsen Study Evaluates Cardiac Conduction Impact in Healthy Volunteers

CAPTURE AMI Trial Evaluates Mechanical Thrombectomy in STEMI Patients

Study on Phoenixin-14 Levels in Infants of Diabetic Mothers

FDA Grants AP Status for Sotalol Hydrochloride ANDA207428

FDA Approval Letter for Verapamil Hydrochloride ANDA078306

SELECT TAVR Trial to Compare Myval and Evolut Valves in Borderline Annuli Patients

AstraZeneca's Wainua fails primary endpoint in ATTR-CM Phase III trial

SINGLE-AF Trial Evaluates DOACs in Intermediate Stroke Risk Atrial Fibrillation Patients

Innovative MRI Methods for Characterizing Heart Failure With Preserved Ejection Fraction

Study on Non-Invasive Median Nerve Stimulation for Atrial Fibrillation Post-Ablation

Boston Medical Center Study on Ultrasound for Heart Failure Management

FDA Grants Approval for Flecainide Acetate ANDA218093 by OMSAV PHARMA

Torrent Pharmaceuticals submits ANDA for Vericiguat

Pilot Trial on Palliative Care for Advanced Heart Failure Shows Innovative Methodology

NHLBI Study on Dyslipidemias Evaluates Lipid Disorders and Their Impact